THE EFFECT OF SERUM FOLLICULAR PHASE LUTEINIZING-HORMONE CONCENTRATIONS IN HABITUAL ABORTION - CORRELATION WITH RESULTS OF PATERNAL LEUKOCYTE IMMUNIZATION

A prospective study was carried out on 153 couples with recurrent abor tions who desired pregnancy, The object was to determine the incidence of raised luteinizing hormone (LH) levels; to compare the outcome of further pregnancies in habitually aborting women with and without rais ed circulating LH concentrations; and to assess whether the efficacy o f paternal leukocyte immunization is affected in the presence of raise d Lu concentrations. Of the 153 women with recurrent abortions (> 3) i ncluded in this study, 56 (36.6 %) had follicular phase serum LH conce ntrations > 10 mIU/ml, Of the 103 pregnancies that were followed prosp ectively, 65 (63.1%) resulted in a birth of a live infant, There was n o significant relationship between the pregnancy outcome and LH concen trations, Women who underwent immunization with paternal leukocytes ha d significantly more live births (75.8%) than those who were not immun ized (43.6%). However, the live birth rate was lower after paternal le ukocyte immunization in the presence of raised LH concentrations or it raised LH/follicle stimulating hormone (FSH) ratio.