NO DETRIMENTAL EFFECT OF FIBRIN GLUE ON THE REGENERATION OF INTRABONYDEFECTS - A CONTROLLED CLINICAL-TRIAL

This controlled clinical trial evaluated the potential of fibrin glue as a biological carrier to locally deliver guided tissue regeneration (GTR) modulators. 2 controlateral, morphologically similar defects wer e selected in each of 11 patients and randomly assigned to the test (t eflon membrane and fibrin glue) and the control treatment (teflon memb rane alone). Outcomes were assessed at membrane removal as newly forme d granulation tissue and at the 1-year followup in terms of changes in probing attachment level, probing pocket depth, recession of the ging ival margin, probing bone levels and percentage of fill of the intrabo ny defects. Data confirmed that GTR treatment of deep intrabony defect s results in clinically and statistically significant improvements of the clinical parameters. No significant differences, however, were evi denced between the test and the control treatments. It is suggested th at, since fibrin glue did not show detrimental effects on GTR, it coul d be applied as a biological carrier for the delivery of GTR enhancers into the surgical wound.