If hepatitis B vaccination is to be introduced into a universal vaccin
ation programme, it must be given before young people become sexually
active. Two age groups ale of main interest: infants and early adolesc
ents. In Australia, North America and Europe, vaccination programmes f
or infants are well established but not yet for adolescents. From a de
velopmental point of view targeting adolescents seems to be a demandin
g task. Nevertheless, there are examples of successful approaches: e.g
. rubella vaccination in the UK, where since its introduction in 1976
the immunisation coverage among 14-year-olds has remained high at 80-8
5%, or the more recent hepatitis B strategies in Italy and Spain, wher
e young adolescents are included with high success rates. In summary,
whereas the inclusion of HBV vaccine in the infant immunization progra
mme is not a problem in most counties, the approach to adolescents nee
ds more thought.