Variations in detector efficiency induce significant artifacts in reco
nstructed images unless accurate normalization methods are used. Scatt
ered events are detected with significantly different efficiencies tha
n unscattered events because the photons in scattered coincidences arr
ive at the detector at lower energies and over a wide range of angles
of incidence. Current methods work well for septa-extended imaging bec
ause the scatter fractions are low. The large scatter fractions encoun
tered in fully 3D imaging, however, require that these differences be
accounted for. We propose a normalization technique that accounts for
them and show that it yields more uniform images than two other potent
ial methods.