EFFICIENT SYNTHESIS OF 2'-AMINO-2'-DEOXYPYRIMIDINE 5'-TRIPHOSPHATES

Authors
MCGEE DPC VARGEESE C ZHAI YS KIRSCHENHEUTER GP SETTLE A SIEDEM CR PIEKEN WA
Citation
Dpc. Mcgee et al., EFFICIENT SYNTHESIS OF 2'-AMINO-2'-DEOXYPYRIMIDINE 5'-TRIPHOSPHATES, Nucleosides & nucleotides, 14(6), 1995, pp. 1329-1339
Citations number
15
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
6
Year of publication
1995
Pages
1329 - 1339
Database
ISI
SICI code
0732-8311(1995)14:6<1329:ESO25>2.0.ZU;2-Z
Abstract
The synthesis of 2'-amino-2'-deoxypyrimidine 5'-triphosphates is descr ibed. The 2'-amino-2'-deoxyuridine 5'-triphosphate is obtained from ur idine in four steps with 25% overall yield. The 2'-amino-2'-deoxycytid ine 5'-triphosphate is obtained from uridine in seven steps with 13% o verall yield.