SYNTHESIS OF NEW THIAZOLIDINONE NUCLEOSIDE ANALOGS

Authors
GRACIET JC FAURY P CAMPLO M CHARVET AS MOURIER N TRABAUD C NIDDAM V SIMON V KRAUS JL
Citation
Jc. Graciet et al., SYNTHESIS OF NEW THIAZOLIDINONE NUCLEOSIDE ANALOGS, Nucleosides & nucleotides, 14(6), 1995, pp. 1379-1392
Citations number
25
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
6
Year of publication
1995
Pages
1379 - 1392
Database
ISI
SICI code
0732-8311(1995)14:6<1379:SONTNA>2.0.ZU;2-K
Abstract
The synthesis of new thiazolididone nucleoside analogues is described. Among the different proposed synthetic pathways, the condensation of various nucleic bases using TMSOTf and Et(3)N as coupling reagents on a key sulfoxide thiazolidinone intermediate led to the desired compoun ds in a one-pot procedure. Analytical data and NMR studies confirmed t he proposed structure assignment for these compounds.