A NEW APPROACH TO THE SYNTHESIS OF 2-AMINOPURINE-2'-DEOXYRIBOSIDE VIATRI-N-BUTYLTIN HYDRIDE REDUCTION

Authors
SCHMIDT S CECH D
Citation
S. Schmidt et D. Cech, A NEW APPROACH TO THE SYNTHESIS OF 2-AMINOPURINE-2'-DEOXYRIBOSIDE VIATRI-N-BUTYLTIN HYDRIDE REDUCTION, Nucleosides & nucleotides, 14(6), 1995, pp. 1445-1452
Citations number
15
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
6
Year of publication
1995
Pages
1445 - 1452
Database
ISI
SICI code
0732-8311(1995)14:6<1445:ANATTS>2.0.ZU;2-6
Abstract
A simple conversion of guanosine to 2-aminopurine-2'-deoxyriboside is described. Following the synthesis of the 2'-phenoxythiocarbonyl deriv ative of 6-chloroguanosine, 2-aminopurine-2'-deoxyriboside can be prep ared by simultaneous reduction of both the 6- and 2'-position using tr i-n-butyltin hydride as reducing agent. Several oligonucleotides conta ining 2-aminopurine-2'-deoxyriboside have been synthesized.