AN EFFICIENT SYNTHESIS OF 2-[(4-AMINO-1,2-DIHYDRO-2-OXO-1-PYRIMIDINYL)METHOXY]-1,3-PROPANEDIYL-DI-L-VALINATE AN ANTICYTOMEGALOVIRUS AGENT

Authors
GHALI N JOHNSTON AB BEAUCHAMP L NASEREE T SCOTT T FLANAGAN R RODRIGUEZ M
Citation
N. Ghali et al., AN EFFICIENT SYNTHESIS OF 2-[(4-AMINO-1,2-DIHYDRO-2-OXO-1-PYRIMIDINYL)METHOXY]-1,3-PROPANEDIYL-DI-L-VALINATE AN ANTICYTOMEGALOVIRUS AGENT, Nucleosides & nucleotides, 14(7), 1995, pp. 1591-1600
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
7
Year of publication
1995
Pages
1591 - 1600
Database
ISI
SICI code
0732-8311(1995)14:7<1591:AESO2>2.0.ZU;2-9
Abstract
An efficient synthesis for large scale preparation of the titled compo und, a prodrug for the anti-HCMV agent 1-[2-hydroxy-1-(hydroxymethyl)e thoxyl]cytosine, 9, has been developed. The product of each step is ea sily purified by either distillation or recrystallization and the fina l product is obtained in a high overall yield.