Background. Treatment of esophageal perforation, especially when diagn
osed late, remains controversial. Methods. Twenty-eight patients were
treated for thoracic esophageal perforation with reinforced primary re
pair regardless of time of presentation. Results. Fifteen patients wer
e treated early (<24 hours) with no deaths. Two had contained postoper
ative leaks, which healed. Thirteen were treated late (mean, 5.5 days)
with four deaths (3 with healed repairs). Postoperative leaks occurre
d in 7 patients; of the leaks, 4 healed, 2 became a controlled fistula
, and 1 required reoperation. Primary healing with preservation of the
native esophagus was achieved in 25 patients (89%). Among the 18 pati
ents without evidence of sepsis preoperatively, postoperative leaks de
veloped in 2 (11%). Ten patients had evidence of sepsis preoperatively
, and postoperative leaks developed in 7 (70%). Conclusions. Patients
who present with sepsis have an increased risk of postoperative leak a
nd therefore should have the repair buttressed. Overall mortality was
14% and no deaths were due to persistent leaks or mediastinal sepsis.
Reinforced primary repair retains the native esophagus and avoids the
need for later reconstructive operations. In the absence of a nondilat
able stricture or cancer, reinforced primary repair should be performe
d for most thoracic esophageal perforations, early or late.