XENOPUS F-CADHERIN, A NOVEL MEMBER OF THE CADHERIN FAMILY OF CELL-ADHESION MOLECULES, IS EXPRESSED AT BOUNDARIES IN THE NEURAL-TUBE

Development of the vertebrate CNS begins during neurulation when the n eural plate gives rise to the neural tube. During neurulation, the dif ferent regions of the CNS can be identified in part by the appearance of flexures in the walls of the neural tube. Here we report the isolat ion and characterization of F-cadherin; a novel member of the cadherin family of cell adhesion molecules, which is expressed at flexures in the neural tube of Xenopus embryos. We show that F-cadherin is first e xpressed at neural plate stages, that its expression is altered when p atterning of the neural tube is perturbed, and that its expression mar ks boundaries in the neural tube where cell mixing is restricted. Thes e observations suggest that F-cadherin contributes to the regionalizat ion of the neural tube perhaps by mediating differential cell adhesion .