IS AN ELEVATED CIRCULATING MATERNAL HOMOCYSTEINE CONCENTRATION A RISKFACTOR FOR NEURAL-TUBE DEFECTS

Authors
UBBINK JB
Citation
Jb. Ubbink, IS AN ELEVATED CIRCULATING MATERNAL HOMOCYSTEINE CONCENTRATION A RISKFACTOR FOR NEURAL-TUBE DEFECTS, Nutrition reviews, 53(6), 1995, pp. 173-175
Citations number
14
Categorie Soggetti
Nutrition & Dietetics
Journal title
Nutrition reviews → ACNP
ISSN journal
00296643
Volume
53
Issue
6
Year of publication
1995
Pages
173 - 175
Database
ISI
SICI code
0029-6643(1995)53:6<173:IAECMH>2.0.ZU;2-L
Abstract
The mechanism by which folic acid supplementation reduces neural tube defect (NTD) incidence is unknown. Recent evidence suggests that mothe rs with NTD neonates have higher circulating homocysteine concentratio ns compared with controls. This presumably indicates impaired homocyst eine remethylation, resulting in a possible methionine shortage at a c rucial stage of fetal development.