M. Koreeda et Jj. Wu, STEREOSELECTIVE SYNTHESIS OF THE BRASSINOLIDE SIDE-CHAIN BY THE USE OF A 5-EXO-ALPHA-SILYL RADICAL CYCLIZATION-PROTIODESILYLATION SEQUENCE, Synlett, (8), 1995, pp. 850-852
The stereoselective synthesis of the steroid having the brassinolide s
ide chain 2 has been achieved from readily available aldehyde 7 in 8 s
teps and 31% overall yield, featuring a 5-exo-mode of alpha-silyl radi
cal cyclization - protiodesilylation sequence as a means for the key s
tereoselective installment of the 24-methyl group.