A review and meta-analysis of 42 group and single-case studies evaluat
ing antecedent exercise (AE) as a means of reducing disruptive behavio
rs was conducted. Of 16 group studies, 12 produced positive results an
d 4 produced negative results. The weighted mean effect sire, expresse
d as Cohen's d, was .33 with a standard error of .08. Moderator analys
is indicated that studies using direct behavioral observation, hyperac
tive subjects, or nonaerobic exercise obtained greater effects, and th
at studies of higher quality obtained weaker effects. Of 26 single-cas
e studies, 22 produced positive results, 1 produced no effect, and 3 p
roduced negative results. The weighted mean effect size, expressed as
d, was 1.99 with a standard error of .411. Among the single-subject st
udies, moderator analyses were unable to detect statistically signific
ant moderators of effect sire. Information was reviewed suggesting tha
t AE is socially acceptable, can be implemented with treatment integri
ty, and has a benign side effect profile. The extent to which AE is fu
nctionally based remains open to question due to a lack of understandi
ng regarding mechanism of action. Ten hypothesized mechanisms of actio
n are briefly discussed.