ENANTIOSELECTIVE SYNTHESIS OF THE K-REGION TRANS-9,10-DIHYDRODIOL OF BENZO[G]CHRYSENE

Authors
TANG XQ HARVEY RG
Citation
Xq. Tang et Rg. Harvey, ENANTIOSELECTIVE SYNTHESIS OF THE K-REGION TRANS-9,10-DIHYDRODIOL OF BENZO[G]CHRYSENE, Tetrahedron letters, 36(34), 1995, pp. 6037-6038
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
34
Year of publication
1995
Pages
6037 - 6038
Database
ISI
SICI code
0040-4039(1995)36:34<6037:ESOTKT>2.0.ZU;2-4
Abstract
Efficient enantioselective syntheses of both enantiomers of the title compound are achieved (>99% ee) via asymmetric dihydroxylation of a st ilbene-type precursor using Sharpless catalysts followed by intramolec ular biaryl coupling with Pd(PPh(3))(2)Cl-2 This is the first example of direct enantioselective synthesis of a K-region dihydrodiol.