HAMMETT ANALYSIS OF THE INHIBITION OF PANCREATIC CHOLESTEROL ESTERASEBY SUBSTITUTED PHENYL N-BUTYLCARBAMATE

Authors
LIN G LAI CY
Citation
G. Lin et Cy. Lai, HAMMETT ANALYSIS OF THE INHIBITION OF PANCREATIC CHOLESTEROL ESTERASEBY SUBSTITUTED PHENYL N-BUTYLCARBAMATE, Tetrahedron letters, 36(34), 1995, pp. 6117-6120
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
34
Year of publication
1995
Pages
6117 - 6120
Database
ISI
SICI code
0040-4039(1995)36:34<6117:HAOTIO>2.0.ZU;2-3
Abstract
Substituted phenyl-N-butylcarbamates (1) as active site-directed irrev ersible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (K-I), the carbamylation cons tant (k(2)), and the bimolecular rate constant (k(i)). Linear free ene rgy relationships between -logK(I), logk(2), or logk(i) and substituen t constant (sigma) are observed.