NEW SOLID-PHASE SYNTHESIS OF OLIGODEOXYTHYMIDINE PHOSPHORODITHIOATES BY A MODIFIED HOBT-METHOD

Authors
ELDRUP AB FELDING J KEHLER J DAHL O
Citation
Ab. Eldrup et al., NEW SOLID-PHASE SYNTHESIS OF OLIGODEOXYTHYMIDINE PHOSPHORODITHIOATES BY A MODIFIED HOBT-METHOD, Tetrahedron letters, 36(34), 1995, pp. 6127-6130
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
34
Year of publication
1995
Pages
6127 - 6130
Database
ISI
SICI code
0040-4039(1995)36:34<6127:NSSOOP>2.0.ZU;2-G
Abstract
Two new dithiophosphorylating reagents 2a,b and shown to give nucleosi de monomers 3a,b with reactivities suitable for solid phase synthesis. An octamer and a nonamer deoxythymidine phosphorodithioate were prepa red on a TentaGel support with good coupling efficiencies. The product s after deblocking are free from phosphorothioate contaminations (dete ction limit 0.5%).