Mh. Hyun et al., AN IMPROVED CHIRAL RECOGNITION MODEL FOR RESOLVING N-ACYL-ALPHA-ARYL-ALKYLAMINES ON PIRKLE-TYPE PI-ACIDIC CHIRAL STATIONARY PHASES, Journal of liquid chromatography, 18(13), 1995, pp. 2527-2541
Citations number
10
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
An improved chiral recognition model for resolving N-acyl-alpha-arylal
kylamines on Pirkle-type pi-acidic chiral stationary phases (CSPs) has
been proposed based on the chiral resolution trends of a homologous s
eries of N-acyl-alpha-(l-naphthyl)ethylamines on CSPs derived from N-(
3,5-dinitrobenzoyl)-(S)-phenylglycine (CSP 1) and N-(3,5-dinitrobenzoy
l)-(S)-leucine (CSP 2). The chiral recognition model proposed has been
evidenced by its successful application to the explanation of the chr
omatographic resolution trends of a homologous series of N-acetyl-alph
a-(1-naphthyl)alkylamines on CSP 1 and 2 and a homologous series of N-
acyl-alpha-(l-naphthyl)ethylamines and N-acetyl-alpha-(1-naphthyl)alky
lamines on CSP 5, which has the same structure as CSP 1 except the tet
her direction.