MODIFIED HYDROXYAPATITE MICROSPHERES AS IMMUNOADSORBENT FOR PLASMA PERFUSION - PRELIMINARY-STUDY

Authors
PAUL W SHARMA CP
Citation
W. Paul et Cp. Sharma, MODIFIED HYDROXYAPATITE MICROSPHERES AS IMMUNOADSORBENT FOR PLASMA PERFUSION - PRELIMINARY-STUDY, Journal of colloid and interface science, 174(1), 1995, pp. 224-229
Citations number
32
Categorie Soggetti
Chemistry Physical
Journal title
Journal of colloid and interface science → ACNP
ISSN journal
00219797
Volume
174
Issue
1
Year of publication
1995
Pages
224 - 229
Database
ISI
SICI code
0021-9797(1995)174:1<224:MHMAIF>2.0.ZU;2-P
Abstract
An improved solid-support, affinity immunoadsorbent suitable for extra corporeal perfusion of plasma is reported. This consists of hydroxyapa tite microspheres coated with a thin layer of poly(vinyl alcohol) and immobilized phenylalanine as ligand. This adsorbent can remove IgG imm unoglobulins specifically from plasma. The modified adsorbent may be u sed for direct hemoperfusion as a cheaper alternative to plasma adsorp tion therapy by eliminating cell separator for selective removal of an tibodies belonging to immunoglobulin G class. (C) 1995 Academic Press, Inc.