ROLE OF ADF TRX AND ITS INHIBITOR ON THE RELEASE OF MAJOR BASIC-PROTEIN FROM HUMAN EOSINOPHILS/

Authors
KOYANAGI H WAKASUGI N YOSHIMATSU K TAKASHIMA Y YODOI JJ MOMOI M SUDA T KASAHARA T YAMAGUCHI Y
Citation
H. Koyanagi et al., ROLE OF ADF TRX AND ITS INHIBITOR ON THE RELEASE OF MAJOR BASIC-PROTEIN FROM HUMAN EOSINOPHILS/, Biochemical and biophysical research communications, 213(3), 1995, pp. 1140-1147
Citations number
23
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
213
Issue
3
Year of publication
1995
Pages
1140 - 1147
Database
ISI
SICI code
0006-291X(1995)213:3<1140:ROATAI>2.0.ZU;2-9
Abstract
Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), original ly defined as an IL-2 receptor alpha-chain/p55 inducer, has many cytok ine-like activities. We reported that the release of major basic prote in (MBP) from mature eosinophils stimulated with cytochalasin B and C5 a were augmented after preincubation with recombinant ADF/TRX. The add ition of a TRX specific inhibitor, BE40644, suppressed the augmentatio n of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils. (C) 1 995 Academic Press, Inc.