V. Madrigal et al., FATAL MENINGOENCEPHALITIS CAUSED BY SCEDOSPORIUM-INFLATUM (SCEDOSPORIUM PROLIFICANS) IN A CHILD WITH LYMPHOBLASTIC-LEUKEMIA, European journal of clinical microbiology & infectious diseases, 14(7), 1995, pp. 601-603
A fatal case of meningoencephalitis caused by Scedosporium inflatum (S
cedosporium prolificans) in a 5-year-old boy with acute myeloblastic l
eukemia who was given intrathecal treatment is reported. Itraconazole
treatment was ineffective. The fungus was identified on brain sections
at autopsy and was not observed in any other organ. As no other porta
l of entry was detected, meningoencephalitis may have originated via d
irect introduction of the fungus at therapeutic lumbar puncture.