Many recent analyses have reported associations between air pollution
and mortality in U.S. cities. In this paper, we present the results of
regression analyses of daily mortality in Philadelphia during the per
iod 1973-1988. Pollution variables included in the analyses were total
suspended particulates (TSP), sulfur dioxide, and ozone. We controlle
d for the effects of weather on mortality by analyzing mortality separ
ately for each season and explicitly including quintiles of temperatur
e in the regression models. In regression models that consider weather
and pollution variables simultaneously, daily mortality is associated
with hot days in summer [relative risk (RR) for highest quintile of t
emperature = 1.07; 95% confidence interval (CI) = 1.04-1.10], and with
cold days in spring (RR for lowest quintile of temperature = 1.07; 95
% CI = 1.04-1.10), fall (RR for lowest quintile of temperature = 1.05;
95% CI = 1.02-1.08), and winter (RR for lowest quintile of temperatur
e = 1.04; 95% CI = 1.01-1.07). When all three pollution covariates and
weather are considered. simultaneously in the regression model, ozone
is associated with mortality in summer (RR = 1.15; 95% CI = 1.07-1.24
) and sulfur dioxide is associated with mortality in spring (RR = 1.19
; 95% CI = 1.06-133), fall (RR = 1.14; 95% CI = 1.00-1.29), and winter
(RR = 1.21; 95% CI = 1.09-1.35), where the relative risks are for inc
remental changes of 100 parts per billion in ozone and sulfur dioxide
on the previous day. Because the pollution covariates are highly corre
lated, it is premature to single out one specific component as being r
esponsible for the observed association between air pollution and mort
ality.