REARRANGEMENTS INVOLVING 12P12 IN 2 CASES OF CARDIAC MYXOMA

Recently, we reported on the cytogenetic analysis of a case of cardiac myxoma, revealing a 46,XY,der(7)t(7;17)(p21;p11), add (10) (q22), add (12) (p12), del(17)(p11) chromosomal pattern. In this article we pres ent the cytogenetic analysis of another case of cardiac myxoma, in whi ch we found several clonal and nonclonal abnormalities including dicen tric chromosomes and telomeric associations (tas). One of the clonal a berrations was a translocation between chromosomes 1 and 12, involving a breakpoint at 12p12, as observed in the case described earlier. Thi s finding suggest that 12p12 might play an important role in the histo genesis of cardiac myxomas.