Within the very large area of ethical concerns, the following issues a
re considered in this paper: (i) intellectual and career-oriented ambi
tion, combined with the pressure that the competition for funds exerts
, may push certain scientists to make dubious compromises with their c
onscience; (ii) exaggerated priority is sometimes given to the smooth
running of a trial, even at the cost of ignoring some ethical requirem
ents; (iii) it is questionable whether preventive intervention can ade
quately and systematically replace primary prevention based on the ces
sation of exposure to carcinogens; (iv) it is of the utmost importance
to ensure that preventive treatment that is to be administered for lo
ng periods has no adverse effects or that the benefits by far outweigh
the possible risks; (v) the informed consent of participants to the t
rials is essential and it should be obtained on the basis of correct,
complete and clear information; (vi) a different type of informed cons
ent is that of all citizens with regard to risks to which they may be
exposed voluntarily or involuntarily; (vii) there is no justification
for, and it is profoundly unethical to omit, delay, or hide informatio
n that may be relevant to the protection of health. Four examples were
chosen to illustrate the preceding points. Key terms human experiment
ation, informed consent, need for complete and correct information, pr
ivileges of prevention.