SNEDDONS SYNDROME, A NEUROCUTANEOUS DISEA SE - CLINICAL SYMPTOMS AND PATHOLOGICAL ANATOMY OF A CASE WITHOUT DETECTION OF ANTIPHOSPHOLIPID ANTIBODIES

The association of livedo racemosa and cerebrovascular lesions is desc ribed as Sneddon's syndrome. A 50-year-old female presented livedo rac emosa and severe dementia. Cerebral angiography showed irregularities and segmental stenosis of the basic cerebral arteries and almost no fi lling of their branches. CT revealed atrophy, hydrocephalus and multi- infarct-syndrome. Antiphospholipid antibodies were not detected. Post mortem autopsy showed granular atrophy with developement of oligoencep halon and signs of disseminated vasculitis of CNS.