TUMOR-NECROSIS-FACTOR-ALPHA ACTS AS AN AUTOCRINE 2ND SIGNAL WITH GAMMA-INTERFERON TO INDUCE NITRIC-OXIDE IN GROUP-B STREPTOCOCCUS-TREATED MACROPHAGES

Authors
GOODRUM KJ DIERKSHEIDE J YODER BJ
Citation
Kj. Goodrum et al., TUMOR-NECROSIS-FACTOR-ALPHA ACTS AS AN AUTOCRINE 2ND SIGNAL WITH GAMMA-INTERFERON TO INDUCE NITRIC-OXIDE IN GROUP-B STREPTOCOCCUS-TREATED MACROPHAGES, Infection and immunity, 63(9), 1995, pp. 3715-3717
Citations number
15
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
63
Issue
9
Year of publication
1995
Pages
3715 - 3717
Database
ISI
SICI code
0019-9567(1995)63:9<3715:TAAAA2>2.0.ZU;2-Y
Abstract
Nitric oxide production by mouse macrophages treated with group B stre ptococci and gamma interferon was inhibited by cytochalasin B or by an tibody neutralization of macrophage-derived tumor necrosis factor alph a. Phagocytosis-induced tumor necrosis factor alpha is responsible for group B streptococcus-induced nitric oxide production in interferon-t reated macrophages.