CONSTRUCTION AND CHARACTERIZATION OF AN ISOGENIC UREASE-NEGATIVE MUTANT OF HELICOBACTER-MUSTELAE

Authors
SOLNICK JV JOSENHANS C SUERBAUM S TOMPKINS LS LABIGNE A
Citation
Jv. Solnick et al., CONSTRUCTION AND CHARACTERIZATION OF AN ISOGENIC UREASE-NEGATIVE MUTANT OF HELICOBACTER-MUSTELAE, Infection and immunity, 63(9), 1995, pp. 3718-3721
Citations number
30
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
63
Issue
9
Year of publication
1995
Pages
3718 - 3721
Database
ISI
SICI code
0019-9567(1995)63:9<3718:CACOAI>2.0.ZU;2-U
Abstract
Helicobacter mustelae infects the ferret stomach and provides an oppor tunity to study pathogenic determinants of a Helicobacter species in i ts natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced a cid tolerance, This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.