BLEOMYCIN AND FK-565 ENHANCE THE RELEASE OF GM-CSF FROM LPS-STIMULATED BALB C PERITONEAL-MACROPHAGES/

Authors
BLANEY BA TURK JL
Citation
Ba. Blaney et Jl. Turk, BLEOMYCIN AND FK-565 ENHANCE THE RELEASE OF GM-CSF FROM LPS-STIMULATED BALB C PERITONEAL-MACROPHAGES/, Immunopharmacology and immunotoxicology, 17(3), 1995, pp. 451-469
Citations number
47
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Immunopharmacology and immunotoxicology → ACNP
ISSN journal
08923973
Volume
17
Issue
3
Year of publication
1995
Pages
451 - 469
Database
ISI
SICI code
0892-3973(1995)17:3<451:BAFETR>2.0.ZU;2-O
Abstract
The anti-tumour antibiotic Bleomycin, the experimental immunostimulato ry tripeptide FK 565, and the immunosuppressive agent Cyclosporin A we re examined for their in vitro effects on the release of the haemopoie tic cytokine Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) from LPS stimulated BALB/c adherent peritoneal macrophages. FK 565 an d Bleomycin produced an increase in GM-CSF release indicating that the se agents are capable of stimulating peritoneal macrophage populations . Cyclosporin A was found to have no effect.