METASTATIC ASPERGILLUS PANNICULITIS IN TH E CASE OF BLASTIC TRANSFORMATION OF A MYELODYSPLASTIC SYNDROME AND AGRANULOCYTOSIS

We present a 58-year-old patient with disseminated aspergillosis and m etastatic panniculitis. He suffered from agranulocytosis and blastic t ransformation of a myelodysplastic syndrome. The skin lesion showed a single subcutaneous inflammatory nodule, which was clearly shown by hi stolog to be of embolic origin. This clinical presentation has not pre viously been described. Disseminated aspergillosis is found mainly in immunocompromised and neutropenic patients and the mortality is high. The present case demonstrates how histological examination together wi th skin biopsy culture can allow the diagnosis.