THE CLONING OF A HUMAN ABC GENE (ABC3) MAPPING TO CHROMOSOME 16P13.3

The ATP binding cassette (ABC) transporters, or traffic ATPases, const itute a large family of proteins responsible for the transport of a wi de variety of substrates across cell membranes in both prokaryotic and eukaryotic cells. We describe a human ABC protein with regions of str ong homology to the recently described murine ABC1 and ABC2 transporte rs. The gene for this novel protein, human ABC3, maps near the polycys tic kidney disease type 1 (PKD1) gene on chromosome 16p13.3. The ABC3 gene is expressed at highest levels in lung compared to other tissues. (C) 1997 Academic Press