CHLOROPEPTINS, NEW ANTI-HIV ANTIBIOTICS INHIBITING GP120-CD4 BINDING FROM STREPTOMYCES SP .2. STRUCTURE ELUCIDATION OF CHLOROPEPTIN-I

Authors
MATSUZAKI K OGINO T SUNAZUKA T TANAKA H OMURA S
Citation
K. Matsuzaki et al., CHLOROPEPTINS, NEW ANTI-HIV ANTIBIOTICS INHIBITING GP120-CD4 BINDING FROM STREPTOMYCES SP .2. STRUCTURE ELUCIDATION OF CHLOROPEPTIN-I, Journal of antibiotics, 50(1), 1997, pp. 66-69
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
1
Year of publication
1997
Pages
66 - 69
Database
ISI
SICI code
0021-8820(1997)50:1<66:CNAAIG>2.0.ZU;2-G
Abstract
The structure of chloropeptin I, a gp120-CD4 binding inhibitor having a potent anti-HIV activity, was elucidated by H-1 and C-13 NMR experim ents and chemical degradation. It is a peptide antibiotic consisting o f six aryl amino acids residues and an a-ore aryl acid some of which h ave chlorine atoms.