He. Fischer et al., IMPLICATIONS OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II TESTINGIN DONORS AND PATIENTS, Annals of clinical and laboratory science, 25(5), 1995, pp. 373-380
The retroviruses known as Human T-Lymphotropic Virus Types I and II (H
TLV-I and -II) were recognized before the human immunodeficiency virus
(HIV-1). Associated diseases of HTLV-I infection, including a particu
lar kind of leukemia or the development of a specific demyelinating di
sease, have also been observed. Screening of blood donors for antibodi
es to HTLV was mandated in November of 1988. This paper examines the b
iology of HTLV-I and HTLV-II and reviews the testing methods for HTLV-
I/II. Data from 39,908 blood donations of volunteer donors at The Univ
ersity of Texas M. D. Anderson Cancer Center (UTMDACC), Division of La
boratory Medicine, Section of Transfusion Medicine are presented, Init
ially reactive specimens for HTLV antibodies were 158 (0.4 percent), O
f these 0.26 percent or 105 of 39,908 were repeatedly reactive. Eight
hundred and sixty-seven cancer patients were also tested for HTLV anti
bodies. Eight or 0.9 percent were repeatedly reactive for HTLV antibod
ies by enzyme immunoassays (EIA), but only one could be confirmed as p
ositive. HTLV-I/II has a very low incidence in the ambulatory populati
on. The relationship of clinical sequelae and the rate of transmission
of these viruses remain unclear. A readily applicable confirmatory te
st is not yet available. Even significant improvements in the sensitiv
ity and specificity of testing will present ongoing problems for ident
ification of true HTLV carriers. The clinical decision-making process
related to the meaning of these results continues to be difficult.