PORPHYROMONAS-GINGIVALIS FIMBRIA-STIMULATED BONE-RESORPTION IS INHIBITED THROUGH BINDING OF THE FIMBRIAE TO FIBRONECTIN

Authors
KAWATA Y IWASAKA H KITANO S HANAZAWA S
Citation
Y. Kawata et al., PORPHYROMONAS-GINGIVALIS FIMBRIA-STIMULATED BONE-RESORPTION IS INHIBITED THROUGH BINDING OF THE FIMBRIAE TO FIBRONECTIN, Infection and immunity, 65(2), 1997, pp. 815-817
Citations number
24
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
2
Year of publication
1997
Pages
815 - 817
Database
ISI
SICI code
0019-9567(1997)65:2<815:PFBII>2.0.ZU;2-N
Abstract
Our most recent study demonstrated that fibronectin is one of the Porp hyromonas gingivalis fimbria-binding proteins. In this present study, we demonstrate with mouse embryonic calvarial cells that P. gingivalis fimbria-stimulated bone resorption is inhibited by human fibronectin. The fibronectin inhibition was dose and culture time dependent and wa s completely neutralized by antifibronectin antibody. The inhibitory a ction of fibronectin depended on fimbrial interaction with the heparin -binding and cell-attachment domains in the fibronectin structure.