COCCOID AND SPIRAL HELICOBACTER-PYLORI DIFFER IN THEIR ABILITIES TO ADHERE TO GASTRIC EPITHELIAL-CELLS AND INDUCE INTERLEUKIN-8 SECRETION

Authors
COLE SP CIRILLO D KAGNOFF MF GUINEY DG ECKMANN L
Citation
Sp. Cole et al., COCCOID AND SPIRAL HELICOBACTER-PYLORI DIFFER IN THEIR ABILITIES TO ADHERE TO GASTRIC EPITHELIAL-CELLS AND INDUCE INTERLEUKIN-8 SECRETION, Infection and immunity, 65(2), 1997, pp. 843-846
Citations number
23
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
2
Year of publication
1997
Pages
843 - 846
Database
ISI
SICI code
0019-9567(1997)65:2<843:CASHDI>2.0.ZU;2-J
Abstract
Helicobacter pylori exists as an actively dividing spiral form and a n onculturable, but viable, metabolizing coccoid form. Both forms are pr esent in the stomach, but their relative pathophysiologic significance s are unknown. Here we show that the coccoid form of H. pylori, in con trast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells.