THE C-FOS IMMUNOREACTIVITIES IN THE DEVELOPING AND ADULT-RAT CEREBELLA

c Fos immunoreactivities were studied by immunohistochemistry in the d eveloping and adult rat cerebella, c Fos immunoreactivities were obser ved in purkinje cells early in postnatal development (P26 d) and reach ed a peak by P40-P60 d, followed by a decline in the 3-month-old adult . The granule cells revealed c Fos immunoreactivities by P26 d but dec lined until P50 d. Then c Fos immunoreactivities increased in the gran ule layer by P50-P60 d and decreased again in the adult. The deep nucl ei showed c Pos immunoreactivites by P40 d and persisted in the adult. In spite of the difference in the patterns of location in c Fos immun oreactivities from the early postnatal period to adulthood, no decreas e in the amount of c Fos immunoreactivity was evident from immunoblott ing studies, Thus, it is concluded that c Fos immunoreactivities chang e from development to adult, but this does not affect the total amount of c Fos protein expression in the cerebellum.