HIGH ENDOTHELIAL VENULES (HEVS) - SPECIALIZED ENDOTHELIUM FOR LYMPHOCYTE MIGRATION

Authors
GIRARD JP SPRINGER TA
Citation
Jp. Girard et Ta. Springer, HIGH ENDOTHELIAL VENULES (HEVS) - SPECIALIZED ENDOTHELIUM FOR LYMPHOCYTE MIGRATION, Immunology today, 16(9), 1995, pp. 449-457
Citations number
83
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
16
Issue
9
Year of publication
1995
Pages
449 - 457
Database
ISI
SICI code
0167-5699(1995)16:9<449:HEV(-S>2.0.ZU;2-9
Abstract
High endothelial venules (HEVs) are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extra -vasation from the blood. Here, Jean-Philippe Girard and Timothy Sprin ger highlight the unique properties of HEV endothelium, discuss the mo lecular mechanisms controlling HEV specialization and review evidence suggesting that HEVs could play an important role in the pathogenesis of chronic inflammatory diseases.