CHANGES IN ATHEROSCLEROSIS COURSE OBSERVE D AT 25-YEAR INTERVAL IN MALES FROM 9 CIC CITIES AND BALTIC STATES

The trends in atherosclerosis presentation were followed up pathomorph ologically in a two-stage epidemiological survey performed in 9 cities of CIC and Baltic states at 25-year interval. The investigations were conducted in accordance with WHO program. Stage 1 (1963-1968) covered 6121 cases, stage 2 (1985-1989) included 9201 cases. The material was collected on the condition of aortas and coronary arteries from 20-59 -eyar-old males who were residents of the cities of Irkutsk, Yakutsk, Tallin, Tartu, Riga, Kharkov, Yalka, Ashgabad, Bishkek. The 2-stage ex aminations gave evidence for growing severity of atherosclerosis. Risk factor analisis demonstrated an increase in the percentage of males w ith diabetes mellitus and arterial hypertension, in the percentage of overweight males and of those with atherosclerosis engaged in mental w ork. It is found that atherosclerosis undergoes changes within the lif e of one generation (for 20-25 years).