DITEC THERAPEUTIC POTENTIAL IN BRONCHIAL- ASTHMA

Ditec effects on clinicofunctional status were investigated in 15 pati ents with mild and moderate atopic bronchial asthma (ABA) aged 20-50 ( 5 males and 10 females). A single ditec dose had a broncholytic effect along die entire bronchial tree and reduced sensitivity to acetylchol ine. Magnesium sulfate (a single dose 3 mmol Mg2+, pH 6.6, tile soluti on osmolality 260 mmol/l) potentiated ditec action on nonspecific hype rreactivity of the bronchial tree. Four-week ditec course induced no c onsiderable changes hi bronchial permeability, but increased reversibi lity of bronchial obstruction, inhibited sensitivity and response of t he bronchial tree to acetylcholine. Course administration of ditec low ered endobronchial concentration of histamine and lipid peroxidation i ntensity showing antiallergic and antiinflammatory properties of the d rug. Ditec is recommended for ABA and other asthma forms treatment as a Safe and effective modality.