SYNDROME OF INAPPROPRIATE SECRETION OF ANTIDIURETIC - HORMONE IN 2 ELDERLY WOMEN WITH ELEVATED SERUM FLUOXETINE

Objective: Fluoxetine is widely prescribed for depressed patients. Hyp onatremia secondary to inappropriate secretion of antidiuretic hormone has been reported in a few cases associated with routine use of fluox etine, especially in elderly patients. The mechanism has been postulat ed to be linked to the inappropriate secretion of antidiuretic hormone . Serum concentrations of antidiuretic hormone and fluoxetine have not been reported in previously published reports. Case Report: We report two new cases of severe and reversible hyponatremia associated with r outine use of fluoxetine therapy in two elderly women. Fluoxetine-indu ced inappropriate secretion of antidiuretic hormone was confirmed by e levated serum concentrations of antidiuretic hormone and fluoxetine.