INFLUENCE OF SODIUM-NITROPRUSSIDE NO-DONOR ON PSYCHOTROPIC ACTIVITY OF ANGIOTENSIN-II

In this work we compared the influence of sodium nitroprusside [SNP] ( a NO donor) on behavioural effects of angiotensin II [AII] in rats. Th e motility, stereotypy, learning of conditioned avoidance responses an d recall of passive avoidance behaviour allowing to avoid aversive sti mulation were estimated. The intracerebroventricularly injection - 15 min before the experiment - of AII, SNP and AII combined with SNP did not produce changes in psychomotor activity in open field, not signifi cantly accelerated acquisition of conditioned avoidance responses and significantly improved recall of the passive avoidance. AII, SNP and A II with SNP applied immediately before the experiment intensified ster eotypy evoked by apomorphine in the dose of 1 mg/kg and amphetamine in the dose of 7.5 mg/kg given intraperitoneally. These results show tha t; 1) sodium nitroprusside as a donor NO participates in memory and le arning processess, 2) overproduction of NO did not change behavioural effects of AII in these experiments.