THE EFFECT OF HIGH-FRUCTOSE INTAKE ON RENAL MORPHOLOGY AND RENAL-FUNCTION IN RATS

The aim of this study was to investigate the effect of 2-week fructose feeding on plasma lipids renal function and morphology in the rats. P air-fed rats were kept individually in metabolic cages for two weeks a nd given diet containing either 25% fructose or 25% starch (weight/wei ght). After that time under Nembutal anesthesia blood pressure was mea sured intrarterially and blood was withdrawn for cholesterol, triglyce ride, insulin, glucose and 24hrs urine was collected to estimate creat inine clearance. At the end of experiment kidneys were removed and fix ed for microscopic examination. Creatinine clearance was higher by 15% (p < 0,01) in fructose fed rats and microscopic examination revealed moderate mesangial cells proliferation in animals of the same group. N o statistical significant difference was observed with regard to lipid s or glucose and insulin between two groups. Our study suggests that f ructose feeding is associated with hyperfiltration and hyperplasia of mesangial cells in glomeruli.