SUCCESSFUL MANAGEMENT OF CONGENITAL PROTEIN-C DEFICIENCY WITH RECURRENT PREGNANCY LOSS

A 29-year-old woman experienced unexplained intrauterine fetal death ( IUFD) three times, at 16, 27 and 27 gestational weeks. She was found t o be protein C-deficient and the existence of infarction in the placen ta was suspected at 20 weeks' gestation during her fourth pregnancy. B oth heparin and antithrombin III were administered until delivery of a small-for-dates but live baby. Massive infarction in the placenta was evident at term. Anticoagulation with heparin is a useful treatment a pproach for cases of recurrent IUFD with protein C deficiency.