APPLICATION OF A UNIQUE AUTOMATED SYNTHESIS SYSTEM FOR SOLUTION-PHASEPEPTIDE-SYNTHESIS

An automated synthesis system, which is suitable for repetitive synthe ses using similar reaction procedures, was used to synthesize systemat ically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The apparatus has also been applied to the automated synthesis of 10 fragment tripeptide derivatives that are constituents of the hormone PACAP-27. The measured molecular optical rotation values of the library of 125 tripeptides were found to correl ate well with calculated values obtained by summation of the molecular optical rotation values for the constituent amino acids.