SEARCH FOR NATURALLY-OCCURRING SUBSTANCES TO PREVENT THE COMPLICATIONS OF DIABETES .2. INHIBITORY EFFECT OF COUMARIN AND FLAVONOID DERIVATIVES ON BOVINE LENS ALDOSE REDUCTASE AND RABBIT PLATELET-AGGREGATION

Authors
OKADA Y MIYAUCHI N SUZUKI K KOBAYASHI T TSUTSUI C MAYUZUMI K NISHIBE S OKUYAMA T
Citation
Y. Okada et al., SEARCH FOR NATURALLY-OCCURRING SUBSTANCES TO PREVENT THE COMPLICATIONS OF DIABETES .2. INHIBITORY EFFECT OF COUMARIN AND FLAVONOID DERIVATIVES ON BOVINE LENS ALDOSE REDUCTASE AND RABBIT PLATELET-AGGREGATION, Chemical and Pharmaceutical Bulletin, 43(8), 1995, pp. 1385-1387
Citations number
4
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
8
Year of publication
1995
Pages
1385 - 1387
Database
ISI
SICI code
0009-2363(1995)43:8<1385:SFNSTP>2.0.ZU;2-Z
Abstract
An EtOAc extract of Artemisiae Capillari Spica inhibited both bovine l ens aldose reductase (bovine-LAR) and rabbit platelet aggregation, Two simple coumarins, scoparone (1) and scopoletin (2), and three flavono ids, capillarisin (21), cirsimaritin (22) and rhamnocitrin (23), were isolated from this extract, Scoparone (1) and scopoletin (2) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by fo ur types of agent, ADP, PAF, sodium arachidonate and/or collagen, Capi llarisin (21) exhibits a potent inhibitory effect on bovine-LAR, In ad dition, thirteen simple coumarins, five coumarin glycosides and two fl avonoids were tested for their inhibitory effect against bovine-LAR an d rabbit platelet aggregation.