COMPLETE SEQUENCE OF THE BITHORAX COMPLEX OF DROSOPHILA

The bithorax complex (BX-C) of Drosophila, one of two complexes that a ct as master regulators of the body plan of the fly, is included withi n a sequence of 338,234 bp (SEQ89E). This paper presents the strategy used in sequencing SEQ89E acid an analysis of its open reading frames. The BX-C sequence (BXCALL) contains 314,895 bp obtained by deletion o f putative genes that are located at each end of SEQ89E and appear to be functionally unrelated to the BX-C, Only 1.4% of BXCALL codes for t he three homeodomain-containing proteins of the complex. Principal fin dings include a putative ABD-A protein (ABD-AII) larger than a previou sly known ABD-A protein and a putative glucose transporter-like gene ( 1521 bp) located at or near the bithoraxoid (bxd), infra-abdominal-2 ( iab-2) boundary on the opposite strand relative to that of the homeobo x-containing genes.