ANTIBIOTIC GE37468-A - A NEW INHIBITOR OF BACTERIAL PROTEIN-SYNTHESIS.1. ISOLATION AND CHARACTERIZATION

Authors
STELLA S MONTANINI N LEMONNIER F FERRARI P COLOMBO L LANDINI P CICILIATO I GOLDSTEIN BP SELVA E DENARO M
Citation
S. Stella et al., ANTIBIOTIC GE37468-A - A NEW INHIBITOR OF BACTERIAL PROTEIN-SYNTHESIS.1. ISOLATION AND CHARACTERIZATION, Journal of antibiotics, 48(8), 1995, pp. 780-786
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
8
Year of publication
1995
Pages
780 - 786
Database
ISI
SICI code
0021-8820(1995)48:8<780:AG-ANI>2.0.ZU;2-6
Abstract
GE37468 A is a new thiazolyl peptide antibiotic obtained by fermentati on of Streptomyces sp. strain ATCC 55365. It inhibits bacterial protei n synthesis by acting on elongation factor Tu and is structurally and functionally related to the GE2270 class of EF-Tu inhibitors. It is ac tive in vitro against Gram-positive bacteria and Bacteroides fragilis, and protects mice against Staphylococcus aureus infection.