RESISTANCE TO THE POLYETHER IONOPHORE ANTIBIOTIC PANDAVIR (NIGERICIN)IN 2 PRODUCING STRAINS OF STREPTOMYCES

Authors
MONCHEVA PA CHRISTOVA KR IVANOVA IV
Citation
Pa. Moncheva et al., RESISTANCE TO THE POLYETHER IONOPHORE ANTIBIOTIC PANDAVIR (NIGERICIN)IN 2 PRODUCING STRAINS OF STREPTOMYCES, Journal of antibiotics, 48(8), 1995, pp. 811-814
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
8
Year of publication
1995
Pages
811 - 814
Database
ISI
SICI code
0021-8820(1995)48:8<811:RTTPIA>2.0.ZU;2-Y
Abstract
In two pandavir (nigericin) producing strains, Streptomyces hygroscopi cus 155 and Streptomyces albogriseolus 444, an enzyme activity was det ected leading to inactivation of the antibiotic in the presence of ATP -Na-2. Apparently, the observed inactivation is specific for the antib iotic produced by these strains. The nigericin producing strains were also found to be less permeable to pandavir than their non-producing v ariants.