Using in-vivo magnetic resonance morphometry it was investigated wheth
er the midsagittal area of the corpus callosum (CC) would differ betwe
en 30 professional musicians and 30 age-, sex- and handedness-matched
controls. Our analyses revealed that the anterior half of the CC was s
ignificantly larger in musicians. This difference was due to the large
r anterior CC in the subgroup of musicians who had begun musical train
ing before the age of 7. Since anatomic studies have provided evidence
for a positive correlation between midsagittal callosal size and the
number of fibers crossing through the CC, these data indicate a differ
ence in interhemispheric communication and possibly in hemispheric (a)
symmetry of sensorimotor areas. Our results are also compatible with p
lastic changes of components of the CC during a maturation period with
in the first decade of human life, similar to those observed in animal
studies.