PROSTAGLANDINS AND SLEEP

The concept of humoral regulation of sleep was initially proposed by a French neuroscientist, Henri Pieron of Paris, in the first decade of this century. He and his associate Legendre were the first to show the presence of a sleep-inducing substance in the cerebrospinal fluid (CS F) of sleep-deprived dogs. Concurrently and independently, Kuniomi Ish imori of Nagoya University, Nagoya, Japan, employing a similar experim ental approach, also demonstrated a sleep-inducing substance in the CS F of sleep-deprived dogs. During the next 80 years or so, more than 30 so-called endogenous sleep substances have been reported to exist in the brain by numerous investigators, CSF, and other organs and tissues of mammals. However, their physiological relevance has remained uncer tain in most instances. In this review, we shall focus upon our own wo rk concerning the molecular mechanisms of sleep-wake regulation by pro staglandins (PGs) D-2 and E(2), with special emphasis on the recent de velopments during the last several years.