IMPACT OF CYTOGENETIC ABNORMALITIES ON OUTCOME OF BONE-MARROW TRANSPLANTS IN ACUTE MYELOGENOUS LEUKEMIA IN FIRST REMISSION

This study analyzed the impact of cytogenetic abnormalities on outcome of 1516 HLA-identical sibling bone marrow transplants for acute myelo genous leukemia (AML) in first remission reported to the International Bone Marrow Transplant Registry by 188 centers, 708 patients (47%) ha d cytogenetic studies performed, Transplant outcome in these subjects was similar to the 808 in whom cytogenetic studies were not performed, One or more cytogenetic abnormalities were detected in 284 (40%) of s ubjects studied, Relapse rates were higher and leukemia-free survival lower in patients with poor prognosis abnormalities vs those with no a bnormality or with good or intermediate prognosis abnormalities (relat ive risk of relapse 2.40, P < 0.01; relative risk of treatment failure 1.68, P < 0.03), We conclude that cytogenetic abnormalities correlate d with increased relapse in patients treated with chemotherapy. HLA-id entical sibling transplants are similar.