REVERSAL OF SEVERE HEPATIC VENOOCCLUSIVE DISEASE BY COMBINED PLASMA-EXCHANGE AND RT-PA TREATMENT

Authors
ESPIGADO I RODRIGUEZ JM PARODY R CARMONA M DIGON J OLLOQUI E
Citation
I. Espigado et al., REVERSAL OF SEVERE HEPATIC VENOOCCLUSIVE DISEASE BY COMBINED PLASMA-EXCHANGE AND RT-PA TREATMENT, Bone marrow transplantation, 16(2), 1995, pp. 313-316
Citations number
13
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
16
Issue
2
Year of publication
1995
Pages
313 - 316
Database
ISI
SICI code
0268-3369(1995)16:2<313:ROSHVD>2.0.ZU;2-3
Abstract
We report the successful treatment of a case of severe hepatic veno-oc clusive disease (VOD) by combined treatment with exchange plasmapheres is and fibrinolysis with rt-PA. Very advanced alterations of hepatic v ascular circulation, evaluated by Doppler sonography, reverted to norm al after treatment. Severe VOD, defined by McDonald's criteria, produc es a mortality of 98%. This case suggests that this new method of comb ined treatment might contribute to changing the usually bad prognosis of this clinical condition.